細胞特異の核受容体は,腎上腺と性腺の発達と性差異化に不可欠である
1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Cell
|May 20, 1994
まとめ
SF-1をコードするFtz-F1遺伝子は,副腎と性腺の発達に不可欠です. その障害は,腎上腺不全と性差異の障害により,マウスの早期死亡につながる.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 発達生物学 発達生物学について
- 遺伝学 遺伝学とは
背景:
- 孤児核受容体SF-1 (Ftz-F1で符号化) は,腎上皮質細胞におけるステロイドヒドロキシラーゼの調節に関与している.
- その正確な役割は,生体内および主性ステロイド性組織の発達において,まだ完全に解明されていない.
研究 の 目的:
- SF-1をコードするFtz-F1遺伝子が,未傷のマウスの腎上腺と性腺の発達と機能における重要な役割を調査する.
主な方法:
- マウスにおけるFtz-F1遺伝子の標的型遺伝子破壊.
- Ftz-F1ヌル動物の発達のフェノタイプと生存率の観察.
- 副腎と性腺の形成,およびコルチコステロンのレベルの評価.
主要な成果:
- すべてのFtz-F1ゼロマウスは,正常な子宮内生存にもかかわらず,産後8日目に死亡しました.
- Ftz-F1のヌル動物には副腎や性腺が欠けていた.
- コルチコステロンの深刻な欠乏が観察され,アドレノ皮質不全を示唆しました.
- オス・マウスとメス・ヌル・マウスの両方とも,完全な性腺発芽とともに,女性の内生殖器を現した.
結論:
- Ftz-F1遺伝子は,腎上腺と性腺の形成に不可欠である.
- SF-1は性差異化において重要な役割を果たします.
- Ftz-F1遺伝子は,一次性ステロイド原生組織の発達に不可欠である.
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