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Updated: Aug 5, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
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T細胞のチロシンキナーゼであるZAP-70の欠陥によるヒトの重症複合免疫不全

M E Elder1, D Lin, J Clever

  • 1Department of Pediatrics, University of California, San Francisco 94143-0110.

Science (New York, N.Y.)
|June 10, 1994
PubMed
まとめ

ZAP-70 (ゼータ鎖関連タンパク質キナーゼ70) の突然変異は,重度の結合免疫不全を引き起こす. この研究は,ZAP-70がT細胞機能に不可欠であり,CD4+とCD8+T細胞のシグナル伝達に異なった影響を及ぼすことを示しています.

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