高血圧患者の24時間の血圧に対するアルコールの繰り返し摂取による二相効果
Circulation
|June 1, 1994
まとめ
一杯のアルコール飲料は,数時間もの間,血圧 (BP) を低下させます. しかし,7日間繰り返し飲むと,いつ BP になるかによって BP が下がったり上がったりします.
科学分野:
- 心血管科学 心血管科学
- 薬理学 薬理学とは
- 高血圧の研究 高血圧の研究
背景:
- アルコール摂取は,血圧 (BP) の変化と関連しています.
- 血圧測定に対するアルコール摂取のタイミングは,観察された関連性に影響を与える可能性があります.
- これらの時間的動態を理解することは,アルコールのBPへの影響の正確な評価に不可欠です.
研究 の 目的:
- アルコールの24時間の血圧に対する急性および慢性的な影響を調査するために.
- BPパターンに対する単回対繰り返しアルコール摂取の影響を区分する.
- アルコール摂取後の時間間隔がBP値に与える影響を評価する.
主な方法:
- 本質的な高血圧を患っている14人の男性習慣的飲酒者を対象とした制御研究.
- 参加者は4日間のコントロールフェーズ (非アルコール飲料) を受け,その後7日間のアルコールフェーズ (エタノール,1mL/kg) を受け,両方とも夕食の摂取でした.
- 歩行式BPモニタリングは,両方のフェーズで特定の日に実施されました.
主要な成果:
- 単一のアルコールの摂取は,対照群と比較して,1日目の24時間のBPを大幅に低下させた.
- 単発的および繰り返しアルコールの摂取は,午後6時から真夜中までの間にBPを低下させた.
- 繰り返し摂取した7日後,血圧は,対照群と1日目と比較して,真夜中から午前8時 (6~14時間後) までの間に有意に高かった.
結論:
- アルコール1回摂取は,短期的にBPを抑える効果を発揮する.
- 7日間にわたるアルコールの繰り返し摂取は,二段階的な効果を示します:飲む直後に抑うつ剤,数時間後にプレッシャー剤.
- 偶発的なBP測定にのみ依存すると,高血圧に対するアルコールの慢性的な影響を過大評価する可能性があります.
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