HPV-16E6およびE6-AP複合体は,p53のユビキチン化におけるユビキチンタンパク質リガゼとして機能する

M Scheffner1, J M Huibregtse, R D Vierstra

  • 1Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892.

Cell
|November 5, 1993
PubMed
まとめ

ヒューマン・パピローマウイルス (HPV) は,ユビキチン-プロテオリチス経路を用いて分解するために腫瘍抑制剤p53を標的にします. 研究者は,E1酵素,新しいE2酵素,およびE6-E6-AP複合体を,このプロセスの重要な要因として特定しました.

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