トロンボキサンA2とプロスタサイクリンのバイオシンセシス 肺血管疾患の子供と青少年における
I Adatia1, S E Barrow, P D Stratton
1Developmental Vascular Biology and Pharmacology Unit, United Medical School, Guy's Hospital, London, UK.
Circulation
|November 1, 1993
まとめ
生まれながらの心臓病の子どもは,血栓素 (TX) A2のバイオシンセシスの増加を示し,プロスタサイクリン (PGI2) との不均衡を示しています. この不均衡は肺血管疾患の進行を促し,高齢の患者でも持続する可能性があります.
科学分野:
- ペディアトリック・カルディオロジー
- 肺動脈高血圧 肺動脈高血圧 肺動脈高血圧 肺動脈高血圧 肺動脈高血圧
- 血管生物学 血管生物学
背景:
- 子供における先天性心疾患 (CHD) の病原性は完全に理解されていません.
- トロンボキサン (TX) A2とプロスタサイクリン (PGI2) は,血管機能において対極的な役割を果たしています.
- TXA2とPGI2のバイオシンセシスの不均衡は,CHDにおける肺血管抵抗と血栓形成に寄与する可能性があります.
研究 の 目的:
- CHDの小児におけるTXA2とPGI2のバイオシンセシスを調査する.
- これらのイコサノイドの不均衡が肺血管疾患に寄与するかどうかを判断する.
- CHDの外科矯正後のTXA2およびPGI2メタボリットの変化を評価する.
主な方法:
- 2,3-ディノール-TXB2と2,3-ディノール-6-オクソ-PGF1αの尿排泄量を,心臓病の小児と健康な対照群で測定した.
- 肺血管疾患のリバーシブルとリバーシブルでない患者のメタボリットの排泄を比較した.
- 心臓外科手術後のメタボリート分泌の評価変化.
主要な成果:
- CHDと肺血流の増加を有する小児は,対照群よりも2,3-ディノール-TXB2の分泌量が著しく高かった.
- 2,3-dinor-6-oxo-PGF1αの分泌は,患者と対照群の間で類似していました.
- 手術後,2,3-ディノール-TXB2の分泌は患者で減少し,コントロールレベルに近づきました.
- 進行した肺血管疾患の患者は,TXA2とPGI2の代謝産物比率が高かった.
結論:
- CHDの小児における2,3-ディノール-TXB2排出量の増加は,肺血管TXA2とPGI2のバイオシンセシスの不均衡を示唆しています.
- この不均衡は,CHDにおける肺血管抵抗性の進行を促す可能性があります.
- この不均衡は,高齢で,矯正されていないCHD患者で持続し,疾患の進行に寄与する.
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