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Updated: Aug 9, 2026

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
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L型Ca2+チャネルにおけるCa2+選択性とイオン浸透性の分子決定因子

J Yang1, P T Ellinor, W A Sather

  • 1Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, California 94305.

Nature
|November 11, 1993
PubMed
まとめ

この研究は,カルシウムチャネル内の4つの重要なグルタミン酸残留物が,高親和性カルシウムイオン結合に不可欠であることを明らかにしています. 改変により,これらの残留物は,カルシウム選択性および浸透性にとって極めて重要であり,細胞信号伝達に影響を及ぼすことが示されています.

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