関連する実験動画

Updated: Jul 20, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Cdi1は,ヒトのG1およびS相タンパク質フォスファタゼで,Cdk2と結合する

J Gyuris1, E Golemis, H Chertkov

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.

Cell
|November 19, 1993
PubMed
まとめ

私たちは,サイクリン依存キナーゼインタラクター1 (Cdi1) を発見し,サイクリン依存キナーゼと相互作用する新しいタンパク質フォスファターゼを発見しました. Cdi1 Cdi1 Cdi1 Cdi1 Cdi1 Cdi1 Cdi1 Cdi1 Cdi1 Cdi1 Cdi1

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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
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