高親和性免疫グロブリンE受容体アルファ鎖遺伝子の標的を狙った破壊によってアナフィラキシの廃止
D Dombrowicz1, V Flamand, K K Brigman
1Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852.
Cell
|December 3, 1993
まとめ
高親和性免疫グロブリンE (IgE) 受容体であるFc epsilon RIは,アナフィラキシスを誘発するために不可欠です. この受容体を持たないマウスは,アレルギー反応から保護され,その重要な役割を示した.
科学分野:
- 免疫学 免疫学とは
- アレルギー研究 アレルギー研究
- セルラー・シグナリング
背景:
- マスト細胞とベースフィルは,免疫グロブリンE (IgE) とアレルゲンによって活性化され,アナフィラキシーにおける重要な役割を果たします.
- これらの細胞は,Fc epsilon RI,Fc epsilon RII/CD23,およびMac-2を含む複数のIgE受容体を発現する.
- in vivo アナフィラキシーを誘発するこれらの受容体の特定の役割は,まだ完全に理解されていません.
研究 の 目的:
- アナフィラキシの発生における高親和性IgE受容体 (Fc epsilon RI) の必要性を調査する.
- FcエプシロンRIのIgE依存性アレルギー反応への貢献を in vivoで決定する.
主な方法:
- FcエプシロンRI欠乏マウスの生成.
- これらの遺伝子組み換えマウスにおけるアナフィラキシー発症の評価.
- FcエプシロンRI欠乏マウスと野生型のマウスの間のアレルギー反応の比較.
主要な成果:
- FcエプシロンRI欠乏したマウスは正常な発達とマスト細胞集団を示した.
- これらのマウスは,皮膚性および全身性アナフィラキシーの両方に耐性がありました.
- FcエプシロンRIの欠如は,IgE依存のアナフィラキシー反応を無効にしました.
結論:
- FcエプシロンRIは,IgE依存性アナフィラキシスの開始に不可欠で必要な受容体である.
- FcエプシロンRI機能をターゲットにすることは,アレルギーのタイプに関係なく,アレルギーを治療するための潜在的な治療戦略です.
関連する概念動画
Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Allergic Reactions
Overview
Adrenergic Agonists: Therapeutic Uses
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...


