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関連する概念動画

Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Retroviral Transduction of T-cell Receptors in Mouse T-cells
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T細胞受容体アンタゴニストペプチドは,ポジティブな選択を誘導する.

K A Hogquist1, S C Jameson, W R Heath

  • 1Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle 98195.

Cell
|January 14, 1994
PubMed
まとめ

T細胞の陽性選択はペプチド変異に特異性があり,低効率のリガンドがこの重要な免疫プロセスを媒介する. この研究では,T細胞の発達に影響を与える特定のペプチドアンタゴニストを特定しています.

科学分野:

  • 免疫学 免疫学とは
  • T細胞生物学について
  • 分子免疫学 分子免疫学

背景:

  • ポジティブ・セレクションは,胸腺内のT細胞発達の重要なプロセスです.
  • T細胞のT細胞受容体 (TCR) が自己MHC分子を認識できる場合にのみ,T細胞が成熟することを保証します.
  • 陽性選択を調節する特定のペプチドリガンドの役割は,依然として活発な調査分野です.

研究 の 目的:

  • T細胞の陽性選択におけるペプチドリガンドの役割を調査する.
  • T細胞受容体 (TCR) トランスジェニックモデルのポジティブな選択を誘発できる特定のペプチド変異体を特定する.
  • 陽性選択のペプチド特異性とリガンド密度感受性を理解するために.

主な方法:

  • ベータ2ミクログロブリン欠乏症 (ベータ2M(-/-)) のマウスからの胎児の胸膜葉の臓器培養.
  • Kb.の文脈でオバルブミン257-264に特異的なCD8+T細胞受容体を発現するT細胞受容体 (TCR) トランスジェニックマウスを利用.
  • TCRアンタゴニストペプチドを含む様々なペプチド変異によって誘発されたチモサイト選択の分析.

主要な成果:

  • TCRアンタゴニストペプチドとして特定されたいくつかのペプチド変種は,陽性選択を誘発することが判明しました.

さらに関連する動画

Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Examination of Thymic Positive and Negative Selection by Flow Cytometry

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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関連する実験動画

Last Updated: May 3, 2026

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10:14

Retroviral Transduction of T-cell Receptors in Mouse T-cells

Published on: October 23, 2010

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Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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  • 選択されたチモサイトは成熟したCD8+T細胞フェノタイプを示し,抗原に反応した.
  • 特定のペプチド (E1) はベータ2M(-/-) マウスのポジティブな選択を誘導したが,ベータ2M(+/-) マウスのネガティブな選択を誘導し,優れたペプチド特異性を示した.

    • 結論:

    • 陽性選択はペプチドリガンドに高度に特異的であり,TCR抗体変異体でもそうである.
    • このプロセスは,非常に低いリガンド密度に対して敏感です.
    • 低効率のリガンドは,陽性選択を媒介するようで,T細胞発達の微妙なメカニズムを強調している.