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関連する概念動画

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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関連する実験動画

Updated: Jun 19, 2026

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis
07:49

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis

Published on: August 27, 2011

ドロソフィラ・ヘッジホッグは,細胞パターニングの形態原体として作用する.

J Heemskerk1, S DiNardo

  • 1Department of Physiology, Columbia University, New York, New York 10032.

Cell
|February 11, 1994
PubMed
まとめ

ドロソフィラ胚のエングレイリング発現細胞は,組織者として働き,ヘッジホッグ (hh) 遺伝子を介して細胞運命を制御します. hhレベルを調節することは,濃度に依存する形態原体として機能することを示唆しています.

科学分野:

  • 発達生物学 発達生物学とは
  • 遺伝学 遺伝学とは
  • 分子生物学は分子生物学である.

背景:

  • 胚形成は,細胞タイプをパターン化するために,オーガナイザー領域に依存しています.
  • ドロソフィラのセグメンタルパターニングの正確なメカニズムは複雑です.

研究 の 目的:

  • ドロソフィラの表皮のエングレイリング発現細胞のオーガナイザー特性を調査する.
  • 胚形成中の細胞型分化を媒介するヘッジホッグ (hh) 遺伝子の役割を明らかにする.

主な方法:

  • ドロソフィラ・エピダーミスの発現細胞を分析した.
  • 胚におけるヘッジホッグ (hh) 遺伝子発現レベルを調節する.
  • HHと無翼の信号伝達経路の相互作用をモデル化する.

主要な成果:

  • エングレイライド発現細胞は,オーガナイザー特性を発揮し,表皮細胞の分化に影響を与える.
  • エッジホッグ (hh) 遺伝子は,このパターニング機能を媒介する.
  • エッジホッグ (hh) は,モルフォゲンとして作用し,濃度に依存した方法で細胞の運命を指定します.

結論:

さらに関連する動画

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

関連する実験動画

Last Updated: Jun 19, 2026

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis
07:49

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis

Published on: August 27, 2011

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

  • エングレイリング発現細胞は,ドロソフィラ・エピダーミスの重要な組織者である.
  • ヘッジホッグ (hh) 信号伝達は,セグメンタル細胞タイプの多様性を確立するために重要である.
  • hhと無翼信号を統合したモデルは,セグメンタルパターンを説明します.