経皮電気神経刺激が冠動脈の血流に与える影響
A Chauhan1, P A Mullins, S I Thuraisingham
1Regional Cardiac Unit, Papworth Hospital, Papworth Everard, Cambrdige, England, UK.
Circulation
|February 1, 1994
まとめ
皮膚経由の電気神経刺激は,アンギナと冠動脈疾患の患者の冠動脈の血流速度を大幅に増加させた. これは神経刺激を示唆しています.
科学分野:
- 心臓病学 心臓病学
- 神経科学は神経科学である.
- 生理学 生理学とは
背景:
- 神経刺激はアンギナ・プクタースの治療に有望だが,そのメカニズムは不明である.
- 神経刺激が冠動脈循環に与える影響を理解することは,治療上の応用において極めて重要です.
研究 の 目的:
- 冠動脈の血流に対する皮膚経電気神経刺激 (TENS) の影響を調査する.
- 心血管疾患における神経刺激の作用メカニズムを解明する.
主な方法:
- 34人のX症候群患者,15人の冠動脈疾患患者,そして16人の心臓移植受容者を研究した.
- TENS前後のドップラー超音波を用いた冠動脈血流速度 (CBFV) の測定.
- 冠動脈直径とエピネフリン濃度の評価された変化.
主要な成果:
- TENSは,X症候群と冠動脈疾患群において,静止CBFVを有意に増加させた (P < .001).
- 心臓移植を受けた患者ではCBFVの有意な変化は見られなかった.
- エピネフリン濃度は,アングイナ (P = .01) の患者で有意に低下しました.
結論:
- 皮膚経由の電気神経刺激は,静止している冠動脈の血流速度を効果的に高めます.
- このメカニズムは,神経経路によって媒介される微循環効果を含む可能性が高い.
- TENSは,冠動脈の流れの障害を含む状態のための治療的アプローチを提供することができます.
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