家族歴と乳がんリスクに関する包括的な評価. ユタ州の人口データベース
1Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City 84132.
JAMA
|October 6, 1993
まとめ
乳がんの家族歴は,女性のリスクを大幅に高め,遠い親戚でさえも,より高い確率に寄与します. 乳がん症例の約17%から19%は遺伝的傾向に関連しています.
科学分野:
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
- エピデミオロジー エピデミオロジー
背景:
- 家族歴は,乳がんの既知の危険因子です.
- ファミリアリスクの範囲を理解することは,リスク評価と予防戦略にとって極めて重要です.
研究 の 目的:
- 乳がんリスクに対する家族歴の影響を評価する.
- 広範なデータセットを使用して,家族歴と乳がんの発症の関連性を定量化します.
主な方法:
- ケース・コントロール・スタディ・デザインが採用されました.
- ユタ州の人口データベースを利用し,血統,がん,死亡率データをリンクした.
- 乳がんと診断された女性と,がん歴のないマッチングコントロールを含む.
主要な成果:
- 最も高い家族歴のスコアを持つ個体では,乳がんのリスクが3倍に増加することが観察されました.
- 乳がんの確率比 (OR) は,一級親族では2.45,二級親族では1.82,三級親族では1.35でした.
- 家族歴は,人口における乳がん症例の推定17%から19%を占めている.
結論:
- 乳がんの家族歴のある女性は,第3度の親戚であっても,リスクが高まります.
- 家族歴は,乳がんの発症の有意で定量化可能な危険因子です.
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