サブグループAのレセプターは,低密度のリポプロテイン受容体に関連しています
P Bates1, J A Young, H E Varmus
1Department of Microbiology and Immunology, University of California, San Francisco 94143-0502.
Cell
|September 24, 1993
まとめ
細胞受容体はレトロウイルスの侵入の鍵です. 研究者らは,小型の低密度リポプロテイン受容体に関連するタンパク質を,RusサルコマウイルスのサブグループAの細胞受容体として特定し,細胞への侵入を可能にしました.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 分子生物学は分子生物学である.
- 細胞生物学 細胞生物学
背景:
- 細胞受容体は,レトロウイルスの宿主細胞への侵入に不可欠です.
- 以前の研究で,Rousの肉腫ウイルスのサブグループA (RSV(A)) に対する感受性を与える鶏の遺伝子を特定しました.
研究 の 目的:
- RSVで関与する細胞受容体を特定し,特徴づけること.
- RSVの分子メカニズムを明らかにするために.
主な方法:
- 鶏の感受性遺伝子のクワイルドホモログの分離.
- 細胞受容体をコードする代替的にスプライスされた処理された遺伝子の生成と分析.
- 感受性を評価するために,哺乳類の細胞で特定された遺伝子の発現.
- ウイルス感染を阻止するために抗体の使用.
主要な成果:
- RSV (A) の細胞受容体をコードする2つの代替的にスプライスされた遺伝子が特定されました.
- 予測される受容体タンパク質は,低密度リポプロテイン受容体 (LDLR) に似た共有された細胞外ドメインを持つ小さな,膜関連である.
- これらの遺伝子の発現は,哺乳類の細胞におけるRSV (A) に対する特定の感受性を授与した.
- この受容体を標的とした抗体は,鳥類の細胞におけるRSV (A) 感染を阻害した.
結論:
- 小型のLDLRに関連するタンパク質は,RSVの細胞受容体として機能する.
- これらの受容体は,RSVの特定の侵入を媒介する.
- これらの受容体を理解することは,特定のレトロウイルスに対する抗ウイルス戦略の開発に不可欠です.
関連する概念動画
Receptor-mediated Endocytosis
Overview
Enzyme-linked Receptors
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Receptor-mediated Endocytosis
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...


