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Updated: May 1, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions
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Published on: April 23, 2011

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BCR-ABL誘発腫瘍生成は,GRB-2アダプタタンパク質のSH2ドメインとの直接相互作用によって媒介されます

A M Pendergast1, L A Quilliam, L D Cripe

  • 1Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710.

Cell
|October 8, 1993
PubMed
まとめ

BCR-ABLオンコタンパク質は,チロシン177経由でGRB-2に結合し,白血病発症に不可欠なRasシグナリングを活性化します. この部位での変異はGRB-2の結合と変換を阻害し,Ras経路の腫瘍性作用を強調する.

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