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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Healing I: Introduction

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関連する実験動画

Updated: Jul 28, 2026

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

犬の肝臓の再生における成長刺激因子

T E Starzl, A F Jones, J Terblanche

    Lancet (London, England)
    |January 20, 1979
    PubMed
    まとめ

    犬の肝臓の再生から得られた肝臓の抽出物は,肝臓細胞の増殖を刺激し,縮を抑制します. これは,インスリンやグルカゴンとは異なる新しい成長制御因子が存在することを示唆しています.

    科学分野:

    • 肝臓病理学 肝臓病理学
    • 再生医学は,再生医療である.
    • 分子生物学は分子生物学である.

    背景:

    • ポータカヴァルシャント (エック) は肝臓の縮と肝臓細胞の損傷を誘発する.
    • 肝臓は,損傷後の再生のための驚くべき能力を有しています.
    • 肝臓の成長と再生を調節する要因は完全に理解されていません.

    研究 の 目的:

    • 肝臓再生と縮に対する再生性肝臓抽出物の効果を調査する.
    • 肝臓組織の再生における潜在的な成長制御因子を特定する.
    • これらの要因が,エックの効果を相殺できるかどうかを判断する.

    主な方法:

    • 肝切除術は犬に施され,その後24,48,72時間の再生期間が続きました.
    • 再生する肝臓からの抽出物は,Eck fistulaを持つ犬のポータル静脈に注入されました.
    • 肝臓の葉は,増殖反応,縮,および輸液後2日と3日の超構造的変化について分析されました.

    主要な成果:

    • 48時間および72時間の再生性肝臓抽出物の注入は,主に左肝葉で,遅延した増殖反応を誘導しました.
    • これらの抽出物は,縮を逆転させ,エックフィスチュラによって引き起こされる肝細胞の悪化を防止しました.

    さらに関連する動画

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    Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research
    08:39

    Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

    Published on: January 31, 2022

    関連する実験動画

    Last Updated: Jul 28, 2026

    Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
    10:42

    Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

    Published on: May 13, 2016

    Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
    05:20

    Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

    Published on: June 29, 2021

    Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research
    08:39

    Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research

    Published on: January 31, 2022

  • ピーク応答は,抽出物の注入から3日後に発生した.

    • 結論:

    • 再生性肝臓エキスには,肝臓の増殖を促進し,縮から保護する要因が含まれています.
    • これらの要因は,インスリンとグルカゴンとは異なる.
    • この発見は,肝臓の再生をターゲットとした治療戦略の道を開く.