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Updated: May 11, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
15:54

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

Published on: June 14, 2014

マウスの発達中のXistの発現は,X染色体不活性化の開始における役割を示唆しています

G F Kay1, G D Penny, D Patel

  • 1Section of Comparative Biology, Medical Research Council Clinical Research Centre, Harrow, England.

Cell
|January 29, 1993
PubMed
まとめ

マウスXist遺伝子は,プロセスそのものに先立って,X染色体不活性化を開始します. 初期の発達におけるそのインプリント表現は,Xistが父親のX不活性化を引き起こし,Xceアレルはこの効果を調節することを示唆しています.

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Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation12:42

Quick Fluorescent In Situ Hybridization Protocol for Xist RNA Combined with Immunofluorescence of Histone Modification in X-chromosome Inactivation

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Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome11:15

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

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X-Inactivation01:58

X-Inactivation

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The Y Chromosome Determines Maleness

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Dosage Compensation

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In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with  distinct numbers of X chromosomes will have...
X-inactivation01:58

X-inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.