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Updated: Aug 14, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
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アルツハイマー・アミロイドタンパク質前駆体複合体と脳GTP結合タンパク質G ((o))

I Nishimoto1, T Okamoto, Y Matsuura

  • 1Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

Nature
|March 4, 1993
PubMed
まとめ

アルツハイマー病には,アミロイド前駆タンパク質 (APP) の変化が伴う. この研究では,APPが受容体として作用し,G ((o)) タンパク質と複合体を形成し,異常なAPP-G ((o)) 信号伝達がアルツハイマー病の病原化に寄与することを示唆しています.

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