甲状腺の樹状細胞とT細胞は,共通の前駆体集団から甲状腺で同時に発達する
1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Nature
|April 22, 1993
まとめ
新たに特定されたチムスリンパ球前駆体と骨髄幹細胞は,デンドリート細胞とT細胞を生成することができます. 甲状腺におけるこの関連した発達は,T細胞の自己耐容性にとって決定的かもしれない.
科学分野:
- 免疫学 免疫学とは
- 発達生物学 発達生物学とは
- ヘマトポエシス (血球形成) とは
背景:
- デンドリット細胞は,リンパ性組織における重要な抗原を呈現する細胞であり,T細胞の選択に不可欠である.
- 甲状腺の樹状細胞は,自己反応性Tリンパ球を排除する上で重要な役割を果たします.
- 成人タイミック dendritic 細胞 (thymus-derived 前駆体 vs. 周辺の移動) の起源は不明のままでした.
研究 の 目的:
- 成人マウスの胸腺で発見された初期のT細胞前駆体の発達可能性を調査する.
- これらの前駆体と骨髄幹細胞が,甲状腺内のデンドリート細胞とT細胞を生成できるかどうかを判断する.
主な方法:
- 成人マウスチムスから初期のT細胞前駆体集団を分離した.
- 先駆体細胞と骨髄の血液形成性幹細胞の静脈内移入は,放射線を浴びた胸膜環境に入ります.
- デンドリット細胞やT細胞集団を含む子孫細胞の分析.
主要な成果:
- 隔離された胸腺リンパ球前駆細胞はBリンパ球を形成しますが,静脈内移植では,赤色素体または骨髄細胞は形成できません.
- 胸膜のリンパ性前駆細胞と骨髄の血液形成性幹細胞の両方が,放射線を受けた胸膜に移植されたときに,デンドリット細胞とT細胞の子孫を生成した.
- 甲状腺内の共通の前駆体からデンドリット細胞とT細胞の関連開発が実証された.
結論:
- 成人タイミック型デンドリティック細胞は,周縁の移動のみからではなく,タイマス内に存在する前体細胞から発達することができます.
- このリンクされた発展は,発達中のT細胞が,効果的ネガティブ・セレクションのために,新たに形成されたチーム dendritic 細胞によって提示された自己抗原と遭遇することを保証します.
- この発見は,T細胞の発達,自己耐性,および胸骨の dendritic 細胞の細胞起源についての洞察を提供します.
関連する概念動画
Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...


