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Updated: Jan 6, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

540

V(D) J再結合シグナルでの割れは,RAG1およびRAG2タンパク質のみを必要とし,2つのステップで発生します

J F McBlane1, D C van Gent, D A Ramsden

  • 1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0540, USA.

Cell
|November 3, 1995
PubMed
まとめ

浄化されたRAG1およびRAG2タンパク質は,信号配列で二重鎖の断絶を生じることによってV(D) J再結合を開始する. このプロセスは,一本の糸をひっくり返し,次にもう一本の糸を壊して,コードの末端のヘアピン構造を形成します.

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