関連する実験動画

Updated: Jul 10, 2026

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
08:51

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound

Published on: May 8, 2012

インテグリン活性化と細胞骨格の相互作用は,線維ネクチンマトリックスの組み立てに不可欠です

C Wu1, V M Keivens, T E O'Toole

  • 1Department of Biochemistry and Molecular Biology Mayo Clinic Scottsdale, Arizona 85239, USA.

Cell
|December 1, 1995
PubMed
まとめ

フィブロネクチンマトリックス形成には,活性化されたインテグリンと特定の結合後の細胞イベントが必要です. この研究は,発育と治癒に不可欠なフィブロネクチン (Fn) アセンブリの鍵となるルールを定義しています.

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Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

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Fibronectins Connect Cells with ECM

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Overview of Cell-Matrix Interactions

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Activation of Integrins

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Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...