分子クローニングとG型肝炎ウイルスの疾患関連:輸血で感染する薬剤

J Linnen¹, J Wages, Z Y Zhang-Keck

¹Genelabs Technologies, Redwood City, CA 94063, USA.

Science (New York, N.Y.)

|January 26, 1996

まとめ

RNAウイルスであるG型肝炎ウイルス (HGV) は,急性肝炎と慢性肝炎を引き起こし,長年持続することがあります. この輸血で感染するウイルスは,米国の献血者も含め,世界中で存在しています.

科学分野:

ウイルス学ウイルス学ウイルス学
肝臓病理学肝臓病理学
感染症感染症は感染症です.

背景:

G型肝炎ウイルス (HGV) は,慢性肝炎の患者で特定されたRNAウイルスです.
HGVは,GBウイルスC (GBV-C) と遺伝的類似性を共有しており,C型肝炎ウイルス (HCV) と遠縁関係にある.

研究の目的:

新しく特定されたG型肝炎ウイルス (HGV) のゲノムと臨床関連性を特徴づける.

主な方法:

補完的なDNAクローンの配列を解析し,HGVの完全なゲノムを決定する.
暗号化されたポリタンパク質を識別するためにウイルスRNAの分析.
肝炎とHGVの関連とウイルス性の持続時間を評価するための臨床データレビュー.

主要な成果:

HGVの完全なゲノムは9392個のヌクレオチドで,2873-アミノ酸ポリタンパク質をコードしています.
HGVは,急性肝炎と慢性肝炎の両方に関連しています.
感染した患者では,最大9年間持続する持続性ウイルス病が観察されました.
HGVは輸血で感染し,世界的な分布があり,米国の献血者から発見されています.

結論:

G型肝炎ウイルス (HGV) は,ウイルス性肝炎の重要な原因であり,長期的な持続の可能性があります.
HGVの世界的な流行と輸血による感染性は,公衆衛生上の重要性を強調しています.

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