超膜チロシンファスファタゼ (DLAR) は,ドロソフィラのモーターアクソン誘導を制御する
N X Krueger1, D Van Vactor, H I Wan
1Division of Tumor Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Cell
|February 23, 1996
まとめ
ドロソフィラ (Drosophila) とは
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学とは
- 分子生物学は分子生物学である.
背景:
- DLARは,ドロソフィラのトランスメブランタンパク質チロシンフォスファタゼである.
- 主に発達中のニューロンで発現する.
研究 の 目的:
- ドロソフィラの発達中のモトニューロンの成長を誘導するDLARの役割を調査する.
主な方法:
- ドロソフィラ胚におけるDlar機能喪失変異の分析.
- セグメンタル神経b (SNb) を含むモーターアクソン経路発見の観察.
主要な成果:
- Dlar変異は,SNbとSNdモーター軸索のパスファインディングエラーを引き起こす.
- ミュータントのSNb軸突は,通常の腹部標的をバイパスする.
- SNaおよびSNc軸突は,Dlar変異によって影響を受けていないようです.
結論:
- DLARは,ドロソフィラの発達中の神経系における特定のモーターアクソンナビゲーションの選択に不可欠です.
- DLARは,特定のモトニューロンが意図した標的に到達する能力を調節する.
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