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血圧と認知症の15年間の縦断研究
I Skoog1, B Lernfelt, S Landahl
1Department of Clinical Neurosciences, Sahlgrenska Hospital, Gothenburg, Sweden.
Lancet (London, England)
|April 27, 1996
まとめ
高血圧の高齢者は,潜在的に小血管疾患を引き起こすことで,認知症のリスクを増やす可能性があります. 認知症発症前に血圧の変化を理解するためにさらなる研究が必要です.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 神経学 神経学とは
- エピデミオロジー エピデミオロジー
背景:
- 血管性認知症は,これまで考えられていたよりも,より一般的かもしれない.
- アルツハイマー病および全般的な認知症発症における高血圧の役割は不明である.
- 血圧と認知機能低下の関連性を調査することは,公衆衛生にとって極めて重要です.
研究 の 目的:
- 70歳以上の人々の血圧と認知症の発症の関係を分析する.
- 高血圧がアルツハイマー病や血管性認知症を含む認知症の発症の危険因子であるかどうかを判断する.
- 高血圧と白質病変の関連性について,老化中の脳で調べる.
主な方法:
- スウェーデン・ゲーテボールの70歳の非認知症患者382人を対象に実施した長期的研究.
- 15年間のフォローアップで,繰り返された包括的な精神医学と身体検査が行われました.
- 認知症発症に関連した70,75,79-85歳の血圧の分析.
主要な成果:
- 79歳から85歳までに認知症を発症した個人は,対照群と比較して70歳でシストリックおよびダイアストリック血圧が著しく高かった.
- 70歳の時における血圧上昇はアルツハイマー病,75歳の時では血管性認知症と関連していた.
- 70歳の高血圧は85歳の白質病変と相関していた.
結論:
- 既存の高血圧は,小血管疾患と白質病変を促進することによって,認知症のリスクを増やす可能性があります.
- 認知症の発症に先立つ血圧の低下は,因果関係を決定するためにさらなる調査を必要としています.
- 血圧と認知症の関連性を理解することで,高齢者の認知健康のための予防戦略を策定することができます.
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