関連する実験動画

Updated: Jul 22, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Rab GDP-解離阻害剤の構造と変異分析

I Schalk1, K Zeng, S K Wu

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Nature
|May 2, 1996
PubMed
まとめ

牛のRab GDP分裂阻害剤 (GDI) の結晶構造は,その2ドメインの組織性を明らかにしています. ラブタンパク質の結合に欠かせない重要な領域は,構造分析と突然変異を介して特定されました.

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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
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