昼夜リズムの転写記憶としてのCREMの適応誘導性
N S Foulkes1, G Duval, P Sassone-Corsi
1Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Nature
|May 2, 1996
まとめ
CREM遺伝子である.
科学分野:
- 分子生物学は分子生物学である.
- クロノバイオロジーはクロノバイオロジーを用います.
- 遺伝子規制 遺伝子規制
背景:
- CREM遺伝子は,哺乳類の昼夜リズムメカニズムに不可欠なICER抑制器をコードします.
- ICERは桃腺でリズム表現を示し,夜にピークに達します.
- 光は,上下神経核 (SCN) を通して,アドレナージ信号伝達とCREB活性化を通じてICERレベルを調節する.
研究 の 目的:
- フォトペリオドが,アドレネルギー刺激に対するCREM遺伝子の反応にどのように影響するかを調査する.
- 光周期依存遺伝子発現を媒介するトランスクリプションのレギュレータの役割を明らかにする.
主な方法:
- 異なる光周期条件下でのCREM遺伝子転写応答の分析.
- CREM遺伝子誘導の制御におけるCREBとICERのバランスの評価.
主要な成果:
- CREM遺伝子の腎上腺刺激に対する感受性は,前の夜の長さに依存しています.
- 光周期の歴史は,CREM遺伝子が誘導に対して過敏または過敏になるかどうかを決定する.
- 差異的反応性は,CREBとICERのダイナミックな相互作用によって支配されます.
結論:
- CREM遺伝子の転写応答は,過去の光周期の"記憶"によって調節される.
- このメカニズムは,サーカディアンシステムが遺伝子発現を季節的変化にどのように適応させるのかについての洞察を提供します.
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