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糖尿病のラットにおける血管機能障害の改善は,経口PKCβ阻害剤によるものです

H Ishii1, M R Jirousek, D Koya

  • 1Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

Science (New York, N.Y.)
|May 3, 1996
PubMed
まとめ

タンパク質キナーゼC (PKC) の活性化に関連した糖尿病血管合併症. 特定のPKC阻害剤であるLY333531は,PKCを阻害することによって,糖尿病のラットにおける腎臓機能と網膜の循環を改善しました.

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...