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Updated: Aug 7, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

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Published on: October 8, 2012

T細胞-受容体親和性およびチモサイト陽性選択

S M Alam1, P J Travers, J L Wung

  • 1Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

Nature
|June 13, 1996
PubMed
まとめ

ペプチド-MHC複合体に対するT細胞受容体 (TCR) 結合親和性は,チモサイト選択の結果を決定する. 特定の親近性窓はポジティブな選択を促進し,より高い親近性はネガティブな選択を誘発し,T細胞の発達を導く.

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