LIMホメオボックス遺伝子Lhx3によって下垂体細胞系統の特異化
H Z Sheng1, A B Zhadanov, B Mosinger
1Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Science (New York, N.Y.)
|May 17, 1996
まとめ
LIMホメオボックス遺伝子Lhx3は,マウスの下垂体発育に不可欠です. その欠如は,ラトケの袋の分化を防止し,皮質栄養菌を除くほとんどの下垂体細胞系に影響を与えます.
科学分野:
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
- エンドクリノロジー エンドクリノロジー
背景:
- pituitary organogenesisは,一般的な原始から複雑な細胞の微分を伴う.
- Lhx3は,下垂体発育に不可欠なLIMホメオボックス遺伝子です.
研究 の 目的:
- 下垂体細胞系統の分化と増殖におけるLhx3の役割を調査する.
- 下垂体細胞の特異性の発達経路を理解するために.
主な方法:
- Lhx3変異を生成するためにマウスの標的遺伝子破壊.
- ホモジゴス型Lhx3変異マウスの下垂体発達の分析.
主要な成果:
- Lhx3変異に同位体を持つマウスは,ラトケ袋の成長と分化に失敗した.
- ミュータントマウスで観察された前頭葉と中頭葉の欠如.
- 皮質栄養菌を除くほとんどの下垂体細胞系統の決定が影響を受けた.
結論:
- Lhx3は,多種多様な下垂体細胞系統の分化と増殖に不可欠です.
- 明確なLhx3-独立経路は,皮質栄養体の初期特異を規定する可能性があります.
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