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Updated: Aug 15, 2026

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
09:40

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Published on: September 28, 2018

T細胞の抗原受容体シグナル伝達におけるSHP-1によるZAP-70の直接的調節

D R Plas1, R Johnson, J T Pingel

  • 1Howard Hughes Medical Institute, Center for Immunology, Washington University Medical School, St Louis, Missouri 63110, USA.

Science (New York, N.Y.)
|May 24, 1996
PubMed
まとめ

タンパク質チロシンファスファターゼSHP-1は,タンパク質チロシンキナーゼZAP-70の活動を低下させることで,T細胞の活性化を否定的に調節する. この相互作用は,抗原受容体の感受性の値を設定する.

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