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Updated: Apr 28, 2026

Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death
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Preparation of Cell-lines for Conditional Knockdown of Gene Expression and Measurement of the Knockdown Effects on E4orf4-Induced Cell Death

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E2F-1はマウスで機能し,アポトーシスを促進し,増殖を抑制します

S J Field1, F Y Tsai, F Kuo

  • 1Division of Neuroscience, Children's Hospital, Boston, Massacusetts, O2115,P5USA.

Cell
|May 17, 1996
PubMed
まとめ

E2F-1 が欠けていたマウスは正常に発達したが,Tリンパ球の発達とチモサイトアポトーシスの欠陥を示した. 高齢のE2F-1ノックアウトマウスも異常な細胞増殖を示し,E2F-1がアポトーシスを調節し,増殖を抑制することを示した.

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