缺血性脳卒中と,日本人の高血圧患者のアンジオテンシン変換酵素の遺伝子
1Department of Internal Medicine, Awaji-Hokudan Public Clinic, Hyogo, Japan.
Circulation
|May 1, 1996
まとめ
ACE挿入/削除 (I/D) ポリモルフィズムのDアレルは,高血圧の日本人の脳卒中のリスクが高いと関連しています. この発見は,ACE I/D遺伝子型が脳血管疾患の独立した危険因子である可能性があることを示唆しています.
科学分野:
- 遺伝学 遺伝学とは
- 心血管疾患 心血管疾患
- 神経学 神経学とは
背景:
- ACE挿入/削除 (I/D) ポリモルフィズムは,様々な集団における心筋梗塞に関連しています.
- ACE I/Dポリモルフィズムと異なる民族の脳卒中との関連に関する研究は限られている.
- 日本人の場合,冠動脈疾患よりも脳卒中がより一般的であり,特に既存の高血圧患者では特にそうである.
研究 の 目的:
- 日本人のACE I/Dポリモルフィズムと高血圧性脳血管疾患との関連を調査する.
- ACE I/D遺伝子型が,高血圧の日本人の脳卒中の危険因子であるかどうかを判断する.
主な方法:
- ACE I/Dポリモルフィズムのゲノタイプ化は,高血圧患者228人と正常血圧患者104人の日本人に実施した.
- 磁気共鳴画像 (MRI) は,ラキュナール心臓発作 (静かなまたは明白な) を検出するために使用されました.
- アレル頻度は,脳卒中と無脳卒中の高血圧患者と,ノルモテンシブ対照群との間で比較されました.
主要な成果:
- ACE*Dアレル頻度は,空白のない患者 (0.31;P<.001) と比較して,高血圧患者で不全性脳卒中 (0.47) で有意に高かった.
- 隙間のない高血圧患者と正常血圧の対照群 (0.34) の間で,ACE*Dアレル頻度の有意な違いは観察されなかった.
- 高血圧患者のACE I/D遺伝子型と不全性脳卒中との関連は,他の既知の危険因子とは無関係でした.
結論:
- 日本人の高血圧患者におけるACE*Dアレルと不全性脳卒中との間の正の関連性がある.
- ACE*Dアレルは,高血圧の個人に脳血管疾患を発症させるための独立した危険因子として機能する可能性があります.
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