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Updated: Aug 4, 2026

09:49
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
血圧の相関値としての赤血球の平均体積
D S Sharp1, J D Curb, I J Schatz
1Honolulu Epidemiology Research Unit, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Honolulu, Hawaii, USA. dan@hhs.cba.hawaii.edu
Circulation
|May 1, 1996
まとめ
高血圧の治療は,赤血球の測定に異なった影響を及ぼします. 非利尿薬による治療は平均体積 (MCV) を低下させ,利尿薬による治療は,おそらく血液粘度経由で,直接的なMCVと血圧の関連性を明らかにする可能性がある.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 血液学 ヘマトロジ
- 心血管医学 心血管医学
背景:
- 臨床研究では,高血圧患者は,正常血圧患者よりも平均体積 (MCV) が低いことが示されています.
- 流行病学的研究は,関係がないか,より高いMCVを示し,矛盾する結果を示しています.
- この研究は,ホノルル・ハート・プログラム内の高齢者のこれらの不一致を調査しています.
研究 の 目的:
- 高血圧の治療,平均体積 (MCV),および血圧のパラメータとの関係を調べる.
- 赤血球数 (RBC) の影響と,MCVとの相互作用が血圧に及ぼす影響を調査する.
- これらの関連を媒介する全血粘性の潜在的な役割を調査する.
主な方法:
- 高齢の男性を3グループに分類する:高血圧治療なし,利尿剤治療,非利尿剤治療.
- 治療グループにおける平均体積 (MCV) の分析.
- MCV,赤血球数 (RBC),シストリック血圧 (SBP),およびダイアストリック血圧 (DBP) の間の相関分析.
主要な成果:
- MCVは,非利尿剤治療群では,未治療群と比較して低かった.
- MCVと血圧の間の逆相関は,未治療および非利尿剤群で観察されました.
- 利尿剤治療は,赤血球を調整した後に,MCVと血圧の間の直接的な関係を明らかにした.
結論:
- 血圧と赤血球の測定値の関係は,全血粘度によって媒介される可能性が高い.
- ヘマトクリトは全血粘度に影響し,これはまた,外周抵抗性および透析血圧に影響する.
- 高濃度の赤血球では,MCVのダウンレギュレーションにより,血流が損なわれることなく,血の粘度および透析血圧が低下する可能性があります.
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