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断続的なクラウディケーションの患者におけるカルニチン関連の変化: 焦点を当てたカルニチン療法のための指示
G Brevetti1, F di Lisa, S Perna
1Department of Medicine, University Federico II, Naples, Italy.
Circulation
|May 1, 1996
まとめ
L-カルニチンのサプリメントは,外周動脈疾患患者の歩行能力を改善する可能性があります. 血アセチルカルニチンのレベルを測定することで,この治療から恩恵を受ける患者を特定することができます.
科学分野:
- バイオケミストリー バイオケミストリー
- 心血管医学 心血管医学
- 栄養科学とは,栄養科学である.
背景:
- 周辺動脈疾患 (PAD) は,カルニチンの代謝の変化と関連しています.
- L-カルニチンのサプリメントは,PADの潜在的な治療戦略です.
研究 の 目的:
- L-カルニチンのカルニチンの代謝および中断性クラウジケーションの患者における歩行能力に対するL-カルニチンの効果を調査する.
- PADにおけるL-カルニチンの反応性の潜在的なバイオマーカーを特定する.
主な方法:
- 血のカルニチンとエステル濃度は,休息状態と運動後の状態で22人のクラウディカン患者と8人の対照群で測定されました.
- 患者はプラセボまたはL-カルニチン (500 mgIV) を投与され,プロトコルは繰り返されました.
- 患者は,休息と運動時のアセチルカルニチン濃度に基づいて2つのグループに分けられました.
主要な成果:
- 2つの患者グループが出現した:一つは,運動に対する正常なアセチルカルニチン反応 (IC1) と,もう一つは,休息時のレベルが上昇し,運動に対する反応が低下した (IC2).
- グループIC2の患者は,グループIC1よりも歩行能力が低い.
- L-カルニチンの投与は,ほとんどのIC2患者で歩行能力を改善し,運動に対するアセチルカルニチンの反応を正常化したが,IC1患者ではそうではなかった.
結論:
- 静止状態および運動後の血アセチルカルニチンのレベルは,L-カルニチン療法に反応する可能性が高い中断性閉塞の患者を特定することができます.
- この評価は,PADにおけるL-カルニチンの治療のためのターゲット集団の選択を導くことができます.
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