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白血病に関連したE2A-HLFキメア転写因子によるアポトーシスの逆転

T Inaba1, T Inukai, T Yoshihara

  • 1Department of Experimental Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nature
|August 8, 1996
PubMed
まとめ

E2A-HLF融合遺伝子は,細胞生存に影響を与えることで白血病を促進します. この腫瘍性タンパク質はアポトーシスを阻害し,白血病発生中に保存された細胞死経路を阻害する役割を示唆しています.

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