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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection08:15

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

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We have developed a protocol for the generation and evaluation of a humanized and human immunodeficiency virus-infected NOG mouse model based on stem cell transplant, intravaginal human immunodeficiency virus exposure, and droplet digital PCR RNA...
9.1K
Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease09:24

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

13.6K
This paper introduces a method for repeated measurements of ventilation and respiratory muscle activity in a freely behaving amyotrophic lateral sclerosis (ALS) mouse model throughout disease progression with whole-body plethysmography and electromyography via an implanted telemetry...
13.6K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

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Here we describe cellular cytotoxicity and single round infectivity assays that allow for the rapid and accurate screening of compounds to determine their cellular cytotoxicity (CC50) and IC50 values against WT and drug resistant...
18.3K
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

32.1K
Quantifying levels of HIV-1 RNA in plasma and sequencing single HIV-1 genomes from individuals with viral loads below the limit of detection (50-75 copies/ml) is difficult. Here we describe how to extract and quantify plasma viral RNA using a real time PCR assay that reliably measures HIV-1 RNA down to 0.3 copies/ml and how to amplify viral genomes by single genome sequencing, from samples with very low viral...
32.1K
Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V311:10

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

12.7K
HIV tropism can be inferred from the V3 region of the viral envelope. V3 is PCR amplified in triplicate using nested RT-PCR, sequenced, and interpreted using bioinformatic software. Samples with with 1 or more sequence(s) with low g2P scores are classified as non-R5...
12.7K
Visualizing Cell-to-cell Transfer of HIV using Fluorescent Clones of HIV and Live Confocal Microscopy13:08

Visualizing Cell-to-cell Transfer of HIV using Fluorescent Clones of HIV and Live Confocal Microscopy

17.0K
This visualized experiment is a guide for utilizing a fluorescent molecular clone of HIV for live confocal imaging...
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関連する実験動画

Updated: Jan 20, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

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HIVに関連した呼吸器疾患

R Miller1

  • 1Department of Sexually Transmitted Diseases, University College London Medical School, UK.

Lancet (London, England)
|August 3, 1996
PubMed
まとめ

HIVに感染した人は,肺疾患,例えばPneumocystis肺炎や細菌感染症などの機会性感染症を含む肺疾患を頻繁に経験する. カポシ (Kaposi) のような結核やがんは,

科学分野:

  • 肺内科 肺内科 肺内科
  • 感染症 感染症は感染症です.
  • 腫瘍学 腫瘍学

背景:

  • HIV感染者は,肺に感染する機会性感染症や腫瘍を発症することが多い.
  • HIV患者の3分の2以上は,少なくとも1回の呼吸器系エピソードを経験しています.
  • 肺胞性肺炎は,予防療法にもかかわらず,依然として一般的です.

研究 の 目的:

  • HIV感染者における一般的な肺合併症の見直しを行う.
  • HIV患者における呼吸器疾患の発生率と種類を強調する.

主な方法:

  • HIV患者における機会性感染症,腫瘍,呼吸器疾患に関する文献レビュー.
  • HIVの肺関節への影響に関する疫学データの分析.

主要な成果:

  • Pneumocystis肺炎は,HIV感染者の呼吸器系疾患の1つである.
  • バクテリア感染症と結核は,罹病率と死亡率の原因が増えています.
  • カポシの肉腫とノンホッジキンリンパ腫は,HIV感染者の肺に一般的に影響を及ぼします.

結論:

  • 肺合併症は,HIV管理において重要な懸念事項である.

さらに関連する動画

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

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関連する実験動画

Last Updated: Jan 20, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
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Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

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  • 呼吸器疾患の早期診断と治療は,HIV患者にとって極めて重要です.
  • 総合的なケアでは,HIV感染における感染性肺疾患と腫瘍性肺疾患の両方に対処する必要があります.