血液透析ユニットにおける慢性肝疾患に関連する非A非B型肝炎
Lancet (London, England)
|May 5, 1979
まとめ
A型肝炎ウイルスは,1968~70年にフルハム病院で発生した非A型非B型肝炎の発生には関与しなかった. この研究では,腎臓病棟患者の急性または慢性肝炎の原因としてA型肝炎ウイルスが除外されました.
科学分野:
- 肝臓病理学 肝臓病理学
- ウイルス学 ウイルス学 ウイルス学
- エピデミオロジー エピデミオロジー
背景:
- 1968年から1970年にかけて,腎臓科で肝炎の発生が発生した.
- 肝炎はHBsAg陰性 (B型肝炎表面抗原陰性) でした.
- その後,ある患者は慢性肝疾患を発症した.
研究 の 目的:
- HBsAg陰性肝炎の発生原因を特定する.
- A型肝炎ウイルス (HAV) が疫病発生における潜在的な役割を調査する.
- その後の慢性肝疾患におけるHAVの役割を評価する.
主な方法:
- 貯蔵された血清サンプルで,抗HAV (A型肝炎ウイルスに対する抗体) の復元性血清検査を行う.
- 感染した29人の患者のうち24人のペア化血清サンプルを分析した.
- 抗HAVタイトルの変化は,時間とともにモニタリングされました.
主要な成果:
- ほとんどの患者では,抗HAVタイトルの有意な増加は検出されなかった.
- 1人の患者は抗HAVタイトルのわずかな増加を示し,2人は抗HAVタイトルの減少を示しました.
- これらの発見は,感染の発生にA型肝炎ウイルスの関与を裏付けなかった.
結論:
- A型肝炎ウイルスが,この急性肝炎の発生の原因である可能性は低い.
- 流行後に観察された慢性肝疾患の原因として,A型肝炎ウイルスは除外されます.
- このアウトブレイクは,おそらく非A非B型肝炎であり,英国の血液透析ユニットで以前報告されていなかったもので,持続的な肝機能不全と関連していた.
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