妊娠の生理学的過剰成長の制御メカニズム
S M Mone1, S P Sanders, S D Colan
1Department of Cardiology, Children's Hospital, Boston, MA 02115, USA.
Circulation
|August 15, 1996
まとめ
妊娠は,心臓の収縮性の一時的な低下を引き起こし,それは血圧と体積の変化によって管理されます. 心臓は,妊娠中および妊娠後の機能を維持するために,そのサイズに適応します.
科学分野:
- 心血管生理学 心血管の生理学
- 生殖医学は,生殖器医学である.
- 心臓のリモデリング
背景:
- 妊娠は,血液動力学的変化による生理学的高縮と縮のモデルとして機能します.
- 妊娠が心室力学に与える影響を調査した.
研究 の 目的:
- 妊娠中の心臓適応がセルボメカニズムとして作用するという仮説を検証する.
- このプロセスの重要なフィードバック変数として壁のストレスを識別します.
主な方法:
- 33人の女性を対象に,正常な妊娠中のおよび後の連続研究を行いました.
- 使用した負荷独立の収縮性指数.
- 監視された心室の寸法,壁の厚さ,そして左心室の質量.
主要な成果:
- 妊娠中に断片的縮小と縮小速度が減少した.
- 心臓指数は増加し,ピーク壁のストレスは早期に上昇し,補償性多動性により正常化しました.
- 左心室の質量変化は,壁のピークストレスと相関しています.
結論:
- 正常な妊娠は,心臓の収縮性の可逆的な低下を伴う.
- 筋収縮機能は,減った余剰負荷によって維持されますが,短期的には減少します.
- 左心室の縮/縮は,血動力学的な負荷と関連しており,これはセルボメカニズムを示唆している.
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