新型WDリピートタンパク質であるFANは,p55 TNF受容体を中性スフィンゴミエリンゼと結合させます

S Adam-Klages1, D Adam, K Wiegmann

  • 1Institut für Immunologie, Christian-Albrechts-Universität Kiel, Federal Republic of Germany.

Cell
|September 20, 1996
PubMed
まとめ

研究者らは,腫瘍死滅因子受容体 (TNF-R55) と結合する新しいタンパク質であるFANを特定した. FANは,中性スフィンゴミエリンゼ (N-SMase) を介してセラミド生成を調節し,TNFシグナル伝達経路の重要なステップです.

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