静止状態および対比運動におけるデジタルスの効果 冠動脈疾患および左心室機能不全の患者における心筋 perfusion
Circulation
|September 1, 1977
まとめ
デジタリスは,冠動脈疾患と左心室機能不全の患者における心筋膜 perfusion を改善します. この研究では,ディゴキシンが運動中にタリウム-201の吸収を増加させ,心臓筋への血流を改善することを示唆しました.
科学分野:
- 心臓病学 心臓病学
- 核心臓病の心臓病学について
- 薬理学 薬理学とは
背景:
- 冠動脈疾患 (CAD) はしばしば心室機能を損なう.
- デジタリスは,収縮性の改善と血管収縮の可能性を含む,心臓機能に知られた効果を持っています.
- 機能不全のCAD患者における心筋注に対するデジタルスの純効果は完全に理解されていません.
研究 の 目的:
- CADと左心室機能不全の患者の運動中の心筋パルフュージョンにディゴキシンが与える影響を調査する.
- ディゴキシンが運動による心筋 perfusion の減少を緩和するかどうかを判断する.
主な方法:
- CADとエジェクション分数<0.50の6人の患者を研究した.
- Thallium-201スシンチグラフィーは,維持ディゴキシンとなしの両方で,休息状態とハンドグリップ運動中に実施されました.
- スチンティグラム画像はコンピュータで処理され,心筋 perfusion を評価するために視覚的に格付けされました.
主要な成果:
- ハンドグリップ運動は,ディゴキシン (25.7〜23.0,P<0.05) を服用していない患者で,シンチグラムスコアを低下させました.
- ディゴキシン投与は,運動中のシンチグラムスコアの有意な変化を防止しました.
- 運動後のスコアは,ディゴキシンを使用した方が,ディゴキシンを使用していない人に比べて有意に高かった (P<0.05).
- 休息時のスコアは,ディゴキシンによって有意に影響されませんでした.
結論:
- タリウム-201の吸収によって評価される心筋膜の perfusion は,CADと左心室機能不全の患者で,デジタルスによって改善されるように見える.
- ディゴキシンは,この患者集団におけるストレス中に心筋血流を保ち,または増強する可能性があります.
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