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Updated: Aug 10, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
12:28

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics

Published on: January 11, 2019

TNFR-1とCD95に関連した死亡領域を含む受容体であるDR3による信号伝導

A M Chinnaiyan1, K O'Rourke, G L Yu

  • 1Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Sciences Inc., 9620 Medical Center Driv.

Science (New York, N.Y.)
|November 8, 1996
PubMed
まとめ

死因受容体3 (DR3) とも呼ばれる腫瘍死滅因子受容体スーパーファミリー12 (TNFRSF12) メンバーは,新しいサイトカイン受容体です. DR3のシグナル伝達にはTRADD,TRAF2,FADD,FLICEが関与しており,リンパ球の恒常性における役割を示唆している.

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