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Updated: Jun 22, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

TNF受容体1エフェクター機能の解剖:JNKの活性化はアポトーシスと関連していないが,NF-kappaBの活性化は細胞死亡を防ぐ

Z G Liu1, H Hsu, D V Goeddel

  • 1Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093-0636, USA.

Cell
|November 1, 1996
PubMed
まとめ

腫瘍死滅因子受容体1 (TNFR1) は,異なる細胞経路を誘発する. 腫瘍死滅因子 (TNF) 信号は,RIP/TRAF2経由でJNKとNF-kappaBを活性化し,FADDはアポトーシスを媒介し,NF-kappaBはTNF誘発死から細胞を保護する.

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