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サイクリンD2は,性腺細胞増殖と腫瘍発生に関与するFSH反応性遺伝子です
P Sicinski1, J L Donaher, Y Geng
1Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA.
Nature
|December 5, 1996
まとめ
この研究は,サイクリンD2がマウスの雌性生殖能力と雄性生殖器の発達に不可欠であることを明らかにしています. その欠乏は不妊症と低プラスティ性丸を引き起こし,ヒトの卵巣がんや丸がんに影響を及ぼします.
科学分野:
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
- 生殖生物学 生殖生物学
背景:
- D型サイクリン (D1,D2,D3) は,哺乳類の細胞周期のG1相を調節する.
- これらのサイクリンは,増殖組織で余剰的に発現し,それらの明確な役割についての疑問を提起します.
研究 の 目的:
- 哺乳類の発達と細胞増殖におけるサイクリンD2の特定の機能を調査する.
- D型サイクリン発現を制御する規制経路を理解する.
主な方法:
- 胚性幹細胞を標的とする遺伝子は,サイクリンD2欠乏したマウスを生み出します.
- ミュータントの男性と女性の生殖フェノタイプの分析.
- 卵巣の花粉細胞における卵泡刺激ホルモン (FSH) によるサイクリンD2誘導の調査.
- 人間の卵巣および丸腫瘍におけるサイクリンD2mRNA濃度の検査.
主要な成果:
- サイクリンD2欠乏症のメスは,FSHへの反応として卵巣の粒状細胞の増殖が低下したため不妊です.
- ミュータントのオスには,低可塑性丸がある.
- サイクリンD2は,グラヌルサ細胞のサイクルAMP依存経路を通じてFSHによって特異的に誘発される.
- 高いサイクリンD2mRNAレベルは,一部のヒトの卵巣および丸腫瘍で発見されています.
結論:
- サイクリンD2は,哺乳類の生殖器官の発達において,重要な非冗長な役割を果たします.
- 異なる細胞内信号伝達経路が,異なるD型サイクリンの発現を調節する.
- サイクリンD2は,ヒトにおける特定の卵巣および臓がんの発生に関与している可能性があります.
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