霊長類のリゾジメのエピソード的適応進化.
1Department of Biological Sciences, University at Albany, State University of New York, 12222, USA.
Nature
|January 9, 1997
まとめ
研究者らは,リゾーザームにおける Darwinian 選択を正し,適応性タンパク質の進化を厳格に実証した. この研究は,哺乳類のタンパク質進化における特定の適応性および浄化性選択エピソードを明らかにしています.
科学分野:
- 進化生物学の進化生物学について
- 分子進化は分子進化である.
- バイオケミストリー バイオケミストリー
背景:
- 種間の同質タンパク質におけるアミノ酸の差異の適応的意義を証明することは,挑戦的でした.
- タンパク質における陽性ダーウィンの選択を検出するための既存の方法には,配列収束と中性率違反が含まれます.
研究 の 目的:
- 同性タンパク質間のアミノ酸差異の適応的意義を厳密に実証する.
- ニュートラルレート違反テストと祖先配列再構築を組み合わせて,ポジティブな選択イベントを特定する.
- 前腸発酵哺乳類およびホミノイドのリゾジームにおける適応進化を調査する.
主な方法:
- ニュートラルレート違反のテストを使用しました.
- 復元された祖先のタンパク質配列.
- 牛やラングル猿から採取したリゾーザムと,ヒト型リゾーザムを分析した.
主要な成果:
- 前腸発酵コロビン猿の共通の祖先に至る系統の正の選択が文書化されている.
- 現代のホミノイド型リソ酵素に繋がる系統に,以前は認識されなかった適応エピソードが検出されました.
- 両方の適応イベントの後に,ネガティブな選択の後のエピソードが観察されました.
結論:
- 組み合わせられたアプローチは,適応的および浄化選択エピソードを効果的に検出します.
- タンパク質の進化過程における特定の系統は,これらの選択イベントのために局所化することができます.
- タンパク質の分子適応を研究するための堅固な方法を提供します.
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