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Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
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細胞外マトリックス硬さは,インテグリン-細胞骨格結合の強化を引き起こす

D Choquet1, D P Felsenfeld, M P Sheetz

  • 1Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Cell
|January 10, 1997
PubMed
まとめ

細胞は感知し,その内部の細胞骨格の結合を強化することによって,マトリックス硬さに反応する. この反応は,抗体結合だけでなく,フィブロネクチン結合に依存しており,脱リン酸化を含んでおり,メカノトキシスの役割を示唆しています.

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