関連する実験動画

Updated: Sep 10, 2026

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
12:29

Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis

Published on: April 16, 2018

PDGFR-β受容体サブユニット発現のアンチセンセスオリゴヌクレオチド抑制は,親密な加厚の抑制を導きます

M G Sirois1, M Simons, E R Edelman

  • 1Harvard-MIT Division of Health Sciences and Technology, Cambridge, Brigham and Women's Hospital (E.R.E.), Boston, Mass, USA. mgsirois@mit.edu

Circulation
|February 4, 1997
PubMed
まとめ

血小板由来成長因子ベータ受容体 (PDGFR-β) を標的としたアンチセンセスのオリゴヌクレオチドは,血管損傷後のネオインティマル形成を著しく減少させた. PDGFR-βの発現抑制またはPDGF-BBによる活性化は,血管疾患の潜在的な治療戦略です.

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