最適な骨のミネラル密度のための閉経後のエストロゲンのタイミング. ランチョ・ベルナードの研究
関連する実験動画
D L Schneider1, E L Barrett-Connor, D J Morton
1Department of Medicine, University of California, San Diego, La Jolla, USA.
JAMA
|February 19, 1997
まとめ
更年期頃にエストロゲン療法を開始し,それを継続することは,最も高い骨のミネラル密度 (BMD) の利点を提供します. しかし,60歳以降にエストロゲンを投与すると,骨を保存する効果も大きくなります.
科学分野:
- エンドクリノロジー エンドクリノロジー
- ゲロントロジーはゲロントロジーの学科です.
- 骨代謝についてです.
背景:
- 閉経後の骨粗鬆症は重大な健康上の問題である.
- エストロゲン療法は,骨の損失を防ぐための一般的な治療法です.
- 骨のミネラル密度 (BMD) のための最適のタイミングとエストロゲン療法の持続時間は,依然として調査の分野です.
研究 の 目的:
- 閉経後のエストロゲン療法の開始タイミングと期間が骨のミネラル密度 (BMD) に与える影響を調査する.
主な方法:
- 60歳から98歳までのコミュニティに住む女性740人を対象とした横断的な研究.
- 骨のミネラル密度 (BMD) は,単光子吸収度測定法 (SPA) と二重エネルギーX線吸収度測定法 (DEXA) を使用して複数の骨格部位で測定されました.
- エストロゲン使用歴の詳細な評価,開始のタイミングと期間を含む,アンケートと薬剤記録を通じて.
主要な成果:
- 更年期で治療を開始した現在のエストロゲン使用者は,決して使用していないユーザーまたは過去のユーザーと比較して,すべての測定サイトで最高BMDを示しました.
- これらのBMDの利点は,主要な骨粗鬆症のリスク要因を調整した後も持続しました.
- 現在の使用者の中で,更年期 (20年使用) または60歳以降 (9年使用) でエストロゲンを開始すると,骨の保存効果が比較可能であることが示されました.
結論:
- 更年期移行期にエストロゲン療法を開始し,長期にわたって継続することは,優れた骨のミネラル密度と関連しています.
- 60歳以降にエストロゲン治療を開始すると,骨の保護にも大きな利点があり,これは早期の開始にほぼ相当します.
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