ポリコンブ群の遺伝子は,アラビドプシスのホメオティック遺伝子発現を調節する
J Goodrich1, P Puangsomlee, M Martin
1John Innes Centre for Plant Science Research, Norwich, UK.
Nature
|March 6, 1997
まとめ
アラビドプシスのCURLY LEAF遺伝子は,花のホメオティック遺伝子を安定的に抑制することによって,細胞運命を維持するために不可欠です. この遺伝子は,この遺伝子です.
科学分野:
- 植物分子生物学 植物分子生物学
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
背景:
- 細胞運命を決定することは,細胞分裂を通して遺伝子の活性状態の安定した遺伝に依存しています.
- ドロソフィラでは,ポリコンブ群とトリソラックス群の遺伝子が,運命決定のためにこれらの状態を維持しています.
- 植物細胞の運命を決定する類似の遺伝子群の役割は完全に理解されていません.
研究 の 目的:
- アラビドプシス・サリアナ (Arabidopsis thaliana) のCURLY LEAF (CLF) 遺伝子の役割を調査する.
- 細胞運命を維持する上で,CLFがポリコンブ群の遺伝子と類似して機能するかどうかを判断する.
- 植物と動物の間の細胞運命を左右する遺伝子調節機構の保存を調査する.
主な方法:
- アラビドプシスのCURLY LEAF遺伝子の遺伝子解析.
- CLF遺伝子産物の分子特性について.
- 既知のポリコンブ群タンパク質とのCLFタンパク質ホモロジーの比較分析.
主要な成果:
- CURLY LEAF遺伝子は,アラビドプシスの植物性ホメオティック遺伝子の安定的な抑制に不可欠です.
- CLF遺伝子は,ポリコンブ群遺伝子の産物であるEnhancer of zesteに同類するタンパク質をコードする.
- このホモロジーは,遺伝子発現状態を維持する機能が保存されていることを示唆しています.
結論:
- CURLY LEAF遺伝子は,安定した遺伝子サイレンスを確保することによって,植物細胞の運命を決定する上で重要な役割を果たします.
- ポリコンブ群の遺伝子は,植物や動物を含む王国における細胞運命を決定する機能が保存されている可能性が高い.
- この発見は,多様な生物の発達安定を維持するための共通の分子機構を強調しています.
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