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Updated: Aug 3, 2026

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
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酸化物質によって媒介されるミトゲンシグナル伝達は,Ras変異した線維芽細胞のRas変異した線維芽細胞で媒介される

K Irani1, Y Xia, J L Zweier

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Science (New York, N.Y.)
|March 14, 1997
PubMed
まとめ

構成的に活性なH-RasV12は細胞を変容させ,超酸化物のような反応性酸素種 (ROS) を増加させます. Ras経路,フラボタンパク質,Rac1を標的とした抗酸化物質と阻害剤は,ROSと細胞成長を抑制し,Ras誘発の変容におけるROSの媒介を示唆した.

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