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The Forced Swim Test as a Model of Depressive-like Behavior
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トリプトファンが急激に枯渇した後のうつ病の再発
K A Smith1, C G Fairburn, P J Cowen
1University Department of Psychiatry, Littlemore Hospital, Oxford, UK.
Lancet (London, England)
|March 29, 1997
まとめ
トリプトファンを枯渇させることで,脳のセロトニン活動を低下させることで,重度のうつ病に罹患しやすい女性のうつ症状を一時的に引き起こす. これはセロトニンをサポートします.
科学分野:
- 神経科学は神経科学である.
- 精神科医は精神病を患っている.
- バイオケミストリー バイオケミストリー
背景:
- 大うつ病の病理生理学は不明だが,セロトニン経路が関与している.
- 選択的セロトニン再吸収阻害剤 (SSRI) は効果的な抗うつ薬であり,セロトニンの役割を示唆しています.
- セロトニン機能の低下とうつ病の発症を結びつける直接的な証拠は不足しています.
研究 の 目的:
- 急性トリプトファンの枯渇が重度のうつ病に弱い個人にうつ病の症状を誘発する可能性があるかどうかを調査する.
- 鬱病のエチオロジーにおけるセロトニン機能の因果的役割を調査する.
主な方法:
- 再発性うつ病歴のある15人の女性を対象とした二重盲検・クロスオーバー研究.
- 参加者は,2つのアミノ酸の混合物を摂取しました:一つはバランスのとれたもので,もう一つはトリプトファンなしです.
- うつ病の症状は,ハミルトン・レーティング・スケール・フォー・デプレッション (HAMD) と自己評価の気分スケールを使用して評価されました.
主要な成果:
- トリプトファンの枯渇はプラズマトリプトファンのレベルを75%大幅に低下させた.
- 15人の参加者のうち10人は,トリプトファンフリー混合物を摂取した後,臨床的に有意なうつ症状を経験しました.
- HAMDスコアは,バランスの取れた混合物と比較して,トリプトファンの枯渇後に大幅に増加しました.
結論:
- 脳のセロトニン機能の急激な低下は,脆弱な個人にうつ病の症状を急激に引き起こす可能性があります.
- これらの発見は,うつ病の発症におけるセロトニン機能の欠乏が重要な役割を果たす証拠を提供します.
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