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NMDA受容体によるNMDA受容体によるNMDA受容体によるNMDA受容体によるNMDA受容体によるNMDA受容体によるP物質の放出に関するNMDA受容体によるNMDA受容体によるP物質の放出に関するNMDA受容体の調節

H Liu1, P W Mantyh, A I Basbaum

  • 1Department of Anatomy, University of California San Francisco, 94143, USA.

Nature
|April 17, 1997
PubMed
まとめ

脊髄におけるN-メチル-D-アスパルテート (NMDA) 受容体の活性化により,物質Pが放出され,持続的な痛みと構造的変化を引き起こす. 物質P受容体または経路をブロックすると,これらの効果が軽減され,新しい痛み治療のターゲットが示唆されます.

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